A Data-Driven Context-Aware Health Inference System for Children during School Closures

Many countries have implemented school closures due to the outbreak of the COVID-19 pandemic, which has inevitably affected children's physical and mental health. It is vital for parents to pay special attention to their children's health status during school closures. However, it is difficult for parents to recognize the changes in their children's health, especially without visible symptoms, such as psychosocial functioning in mental health. Moreover, healthcare resources and understanding of the health and societal impact of COVID-19 are quite limited during the pandemic. Against this background, we collected real-world datasets from 1,172 children in Hong Kong during four time periods under different pandemic and school closure conditions from September 2019 to January 2022. Based on these data, we first perform exploratory data analysis to explore the impact of school closures on six health indicators, including physical activity intensity, physical functioning, self-rated health, psychosocial functioning, resilience, and connectedness. We further study the correlation between children's contextual characteristics (i.e., demographics, socioeconomic status, electronic device usage patterns, financial satisfaction, academic performance, sleep pattern, exercise habits, and dietary patterns) and the six health indicators. Subsequently, a health inference system is designed and developed to infer children's health status based on their contextual features to derive the risk factors of the six health indicators. The evaluation and case studies on real-world datasets show that this health inference system can help parents and authorities better understand key factors correlated with children's health status during school closures. © 2023 ACM.

D-Dimer Elevation Matters to Predict COVID-19 Severity: A Machine Learning Approach

Although previous studies using limited data have documented an association of D-dimer levels with COVID-19 severity, the role of D-dimer in the progression of COVID-19 remains unclear and requires further investigation using data from larger cohorts. We used traditional statistical modeling and machine learning methods to examine critical factors influencing the D-dimer elevation and to characterize associated risk factors of D-dimer elevation over the course of inpatient admission. We identified 20 important features to predict D-dimer levels, some of which could be used to predict and prevent the D-dimer elevation. Laboratory monitoring of D-dimer level and its risk factors at early stage can mitigate severe or death cases in COVID-19. © 2022 IEEE.

US County-level Risk Factors Associated with COVID-19 Exacerbation During the Vaccination Era

The COVID-19 pandemic has caused unprecedented challenges to public health and disruption to everyday life. The news in 2020 was dominated by the worldwide spread of COVID-19, overwhelming healthcare providers and drastically changing people's lives. In 2021, the release of vaccines from multiple pharmaceutical companies changed the focus to ending the pandemic through mass inoculation. Nevertheless, the vaccine acceptance rate differs significantly across US counties, ranging from 99% to 0.1%. Our study investigates the principal risk factors in predicting COVID-19 infection and mortality rates at the county level during the early vaccination era. We are particularly interested in the role of vaccination in curbing the exacerbation of COVID-19. To this end, we first compare the efficacy of six established machine learning algorithms to predict county-level infection and mortality rates. Next, we perform risk factor analysis by identifying common principal predictors revealed by the models. Our experimental results suggest that vaccination plays an essential role in limiting COVID-19 infection and mortality. Furthermore, socioeconomic factors (e.g., severe housing problems and median household income) are more predictive of county-level mortality rate than intuitive features such as availability of healthcare resources (e.g., total numbers of hospitals/ICU beds/MDs). Our findings could provide additional insights to assist in COVID-19 resource allocation and priority setting. © 2022 IEEE.